Reasons

7 Reasons Pet Parents Are Giving Their Dogs This Longevity Supplement Sooner, Not Later.

Could one daily drop really help your dog live longer, feel better, and stay playful for years to come? Thousands of pet parents (and their pups) say yes.

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1. It All Starts at the Cellular Level: Here’s How Pawprint Protocol Extends Your Dog’s Healthspan

As dogs age, their NAD+ levels decline, oxidative stress increases, and mitochondrial function slows down, all of which reduce their longevity. The secret to restoring their vitality starts with key enzymes1,2

Restoring NAD+: NMN is the precursor to NAD+, so by supplementing NMN, you can help boost NAD+ levels at the cellular level. Essentially, NMN acts as a catalyst for sustaining your dog's energy, health, and longevity3
Reducing Oxidative Stress: As NAD+ levels rise, cells become more capable of handling oxidative stress, reducing damage caused by cellular disruptors. This leads to less inflammation, healthier tissues, and a reduction in the risk of age-related diseases4
Supporting Mitochondrial Function: Mitochondrial activity is optimized with increased NAD+ levels. And with improved mitochondrial function, your dog will have the energy they need to stay active, playful, and healthy throughout their life5

Just like in human supplements, the nanoliposomal technology6 in Pawprint Protocol can improve the absorption of nutrients, ensuring they receive the maximum amount of benefits.

By understanding the science behind aging and proactively supporting your dog's cellular health from a young age, you can make a responsible decision that will provide a more vibrant life for your furry companion.

2. Better Joints, More Fetch: How This Formula Supports Mobility & Reduces Inflammation

Dogs can experience stiffness and reduced mobility over time, which can be heartbreaking for pet owners. However, powerful anti-inflammatory agents like CoQ107 and Resveratrol8,9 can help restore energy and improve joint health.

CoQ10 boosts cellular energy and reduces inflammation, easing joint stiffness, while Resveratrol supports better circulation and fights inflammation, improving movement.

By incorporating these powerful ingredients, you can help your dog regain their playfulness and vitality. This isn’t just a temporary fix. It’s a long-term solution to support your dog’s health, allowing them to stay active and happy for years to come.

3. Supports a Healthy Gut10, So Your Dog Feels Better From the Inside Out

A healthy gut supports better digestion, boosts immune function, and helps manage inflammation, leading to improved comfort and long-term health.

By supporting your dog’s gut with Pawprint Protocol, you’re investing in their longevity, helping them absorb nutrients more efficiently and fight off illnesses, ultimately enhancing their healthspan. While your dog can’t tell you when they’re not feeling their best, you can help them feel better by addressing their gut health.

Pawprint Protocol is a science-backed solution to support your dog’s digestion and overall vitality, giving them the best chance for a long, healthy, and happy life.

4. More Chill, Less Bark: Ingredients That Help Keep Your Dog Calm and Happy

Modern pet parents are increasingly aware of the stress factors affecting their dogs, such as overstimulation and separation anxiety. Just like stress accelerates aging in humans, it does the same for dogs by increasing oxidative stress and inflammation11

NMN and CoQ10 help reduce oxidative stress and promote a balanced nervous system, supporting your dog’s ability to manage stress and maintain cellular health12,13

By reducing stress, you’re not just improving your dog’s mood, but also slowing down their aging process. Supporting your dog’s stress management with these ingredients promotes a healthier, longer life, helping them feel calm, balanced, and vibrant.

5. Reignite that sparkle in your dog’s eyes.

Supporting your dog’s health from the inside out leads to visible transformations, like a glossier coat14, brighter eyes15, and improved posture.

Imagine your dog, once sluggish with a dull coat and dim eyes, can now carry themselves with youthful energy.

Using antioxidants like Resveratrol16, you’re helping to fight oxidative damage and protect their skin and fur, leading to a healthier, more radiant appearance. Your dog will look healthy because you’re giving them what they need to thrive.

This transformation is not just about looks. It's a sign of the vitality and energy you’ve helped restore in your dog’s life.

6. Boost your dog’s brainpower.

Watching your dog cognitively decline is tough, especially if they become confused or distant.

However, there’s hope with NAD+ and NMN, which can support your dog’s cognitive function by boosting memory, attention, and brain health17. By enhancing NAD+ levels, these supplements help keep your dog sharp as a tack, allowing them to stay connected and engaged with you.

While aging is inevitable, you can help your dog retain their mental clarity and enjoy a better quality of life as they grow older.

7. From Nap Mode to Play Mode: Where All That Energy Comes From

With decreased energy levels, their desire to play and connect with you can fade over time.

Thankfully, NMN and CoQ10 support natural, sustained vitality, helping your dog regain youthful energy without overstimulation18,19,20

Aging isn’t limited to losing years, but losing excitement and connection. By restoring their energy with these supplements, your dog can become more playful, engaged, and joyful again, allowing you to reconnect and enjoy those bonding moments together.

How Will Your Dog Thrive With Pawprint Protocol?

Pawprint Protocol is designed for dogs of all ages.

Whether you are giving your young pup a stronger start or helping your senior dog stay vibrant, this formula supports their health from the inside out.

By starting early, you can help build a foundation of resilience, sharp thinking, strong joints, and lasting energy. And for older dogs, it is a powerful way to protect what matters most and help them stay playful, mobile, and full of life.

No matter their age, every day with Pawprint Protocol is a chance to strengthen their body, sharpen their mind, and create more years of joy by your side.

Invest in their future today. Because every dog deserves to live healthier, happier, and longer.

Subscribe now and start the transformation.

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References

Simon K.E. et al. — “A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD⁺-precursor combination.” Scientific Reports. https://www.nature.com/articles/s41598-024-63031-w — “Age-related decline in mobility and cognition are associated with cellular senescence and NAD⁺ depletion in dogs and people.”
Head E. et al. — “Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging.” Experimental Neurology. https://doi.org/10.1016/j.expneurol.2009.08.014 — “Aged canine brain mitochondria show significant increases in ROS production and a reduction in NADH-linked respiration.”
You Y. et al. — “Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration.” Frontiers in Pharmacology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770224/ — “Nicotinamide mononucleotide (NMN), a key precursory metabolite of NAD⁺, has been shown to elevate the cellular level of NAD⁺ … in beagle dogs.”
Head E. et al. — “Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging.” Experimental Neurology. https://doi.org/10.1016/j.expneurol.2009.08.014 — “Mitochondrial function (ROS and NADH-linked respiration) was improved selectively in aged dogs treated with an antioxidant
Head E. et al. — “Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging.” Experimental Neurology. https://doi.org/10.1016/j.expneurol.2009.08.014 — “Respiration rates were significantly improved in aged animals when mitochondrial cofactors were provided, approaching levels seen in young dogs.”
Jiang Lu et al. – “Preparation, pharmacokinetics and anti-obesity effects on dogs of [active compound] liposomes.” Veterinary Medicine & Science (2024) – https://pubmed.ncbi.nlm.nih.gov/39239721/ — “The liposome group showed significantly longer half-life and higher relative bioavailability of [active compound] in dogs compared with the free compound, leading to marked anti-obesity effects.”
Natalia Druzhaeva et al. — “Effects of Coenzyme Q10 Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease.” Antioxidants (2022). https://pubmed.ncbi.nlm.nih.gov/35892628/ — “CoQ10 supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration… CoQ10 as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.”
Arkadiusz Grzeczka, Szymon Graczyk, Paweł Kordowitzki — “Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?” Cells 13 (20): 1732 (2024). https://www.mdpi.com/2073-4409/13/20/1732 — “RES supplementation alleviates acute inflammation in dogs by inhibiting NF-κB and simultaneously activating Nrf2.”
Kwan M. H. Ho et al. — “Improved Cardiovascular Tolerance to Hemorrhage after Oral Resveratrol Pretreatment in Dogs.” Veterinary Sciences 8 (7): 129 (2021). https://www.mdpi.com/2306-7381/8/7/129 — “Seven days of oral resveratrol treatment in greyhound dogs improved their blood-pressure tolerance to induced hemorrhage, indicating enhanced circulatory stability.”
Rachel Pilla & Jan S. Suchodolski — “The Role of the Canine Gut Microbiome and Metabolome in Health and Gastrointestinal Disease.” Frontiers in Veterinary Science (2020). https://doi.org/10.3389/fvets.2019.00498 — “The gut microbiome contributes to host metabolism, protects against pathogens, educates the immune system, and, through these basic functions, affects directly or indirectly most physiologic functions of its host.” “A healthy and stable microbiome can simultaneously act as pro- and anti-inflammatory, keeping a balance to prevent excessive inflammation while still being able to promptly respond to infections.” “The composition of the gut microbiota also has significant effects on immune function, and regulates the local production of antibodies.”
Chayanne S. Ferreira et al. — “Alterations to oxidative stress markers in dogs after a short-term stress during transport.” Journal of Nutritional Science 3 :e27 (2014). https://doi.org/10.1017/jns.2014.47 — “TBARS, TAC and DPPH increased … we conclude that the transport model is effective in inducing an antioxidant response in dogs.”
Yingnan You et al. — “Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration.” Frontiers in Pharmacology 11 :604404 (2020). https://doi.org/10.3389/fphar.2020.604404 — “Nicotinamide mononucleotide (NMN), a key precursory metabolite of NAD⁺, has been shown to elevate the cellular level of NAD⁺ and ameliorate various age-related diseases.”
Natalia Druzhaeva et al. — “Effects of Coenzyme Q10 Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease.” Antioxidants 11 (8): 1427 (2022). https://doi.org/10.3390/antiox11081427 — “CoQ10 supplementation had a positive impact on neutrophil and lymphocyte profiles; CoQ10 … may have benefits in terms of decreasing inflammation in dogs”
Miguel Sánchez de Santiago et al. — “Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis.” BMC Veterinary Research 17:354 (2021). https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-021-03063-w — “Dogs fed the antioxidant- and polyphenol-enriched diet had 25 and 49 % reductions in dermatologic severity scores on days 30 and 60 … Polyphenols such as resveratrol are well-studied for anti-inflammatory skin benefits.”
Curtis A. Barden et al. — “Effect of grape polyphenols on oxidative stress in canine lens epithelial cells.” American Journal of Veterinary Research 69 (1): 94-100 (2008). https://pubmed.ncbi.nlm.nih.gov/18167093/ — “Oxidative stress induced in canine lens epithelial cells was reduced by pure resveratrol by about 13.4 %, demonstrating direct antioxidant protection of ocular tissues.”
Arkadiusz Grzeczka & Szymon Graczyk – “Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?” Cells 13 (20): 1732 (2024). https://www.mdpi.com/2073-4409/13/20/1732/ — “Resveratrol supplementation alleviates acute inflammation in dogs by inhibiting NF-κB and simultaneously activating Nrf2.”
Katherine E. Simon et al. — “A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD⁺-precursor combination.” Scientific Reports (2024). https://www.nature.com/articles/s41598-024-63031-w — “We conclude that LY-D6/2 improves owner-assessed cognitive function over a 3-month period… The largest decrease in CCDR (cognitive-dysfunction) score occurred in the full-dose NAD⁺-precursor group.”
Katherine E. Simon et al. — “A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD⁺ precursor combination.” Scientific Reports (2024). https://doi.org/10.1038/s41598-024-63031-w — “The proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full-dose NAD⁺-precursor group than in other groups.”
Natalia Druzhaeva et al. — “Effects of Coenzyme Q10 Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease.” Antioxidants 11 (8): 1427 (2022). https://doi.org/10.3390/antiox11081427 — “CoQ10 supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration… CoQ10 as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.”
Liselotte B. Christiansen et al. — “Pharmacokinetics of repeated oral dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with myxomatous mitral valve disease.” Antioxidants 9 (9): 827 (2020). https://doi.org/10.3390/antiox9090827 — “One owner of each dog was asked to grade exercise intolerance, demeanor, appetite… An overall score ranging 7 to 28 was obtained, with the lowest score indicating the best quality-of-life.”

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This is an advertisement for Pawprint Lab™ and is intended for informational purposes only. All information provided by Pawprint Lab™ does not constitute medical advice and should not be used as a replacement for veterinarian advice. Please consult your veterinarian regarding any change in treatment or supplementation.
The views and opinions expressed are solely those of Pawprint Lab™ or a testimonial from a verified Pawprint Lab™ customer based on his or her real-life experiences. Individual results may vary. While many of Pawprint Lab’s™ testimonials are unsolicited, some consumers received compensation in return for an honest review.
Please note that Pawprint Lab™ products are not drugs and are not intended to treat, prevent, or cure any disease. The use of the logos are copyrighted by each respective entity, and use of any particular logo may represent a publication, advertisement, or mention of Pawprint Lab™ on a local affiliate or regional carrier.

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1. It All Starts at the Cellular Level: Here’s How Pawprint Protocol Extends Your Dog’s Healthspan

2. Better Joints, More Fetch: How This Formula Supports Mobility & Reduces Inflammation

4. More Chill, Less Bark: Ingredients That Help Keep Your Dog Calm and Happy

5. Reignite that sparkle in your dog’s eyes.

6. Boost your dog’s brainpower.

7. From Nap Mode to Play Mode: Where All That Energy Comes From

How Will Your Dog Thrive With Pawprint Protocol?

Country/region

Pawprint Protocol

Pawprint Wellness Protocol

Pawprint Grounding Pet Mat

Pawprint Repellent Collars

Pawprint Calming Collars

1. It All Starts at the Cellular Level: Here’s How Pawprint Protocol Extends Your Dog’s Healthspan

2. Better Joints, More Fetch: How This Formula Supports Mobility & Reduces Inflammation

4. More Chill, Less Bark: Ingredients That Help Keep Your Dog Calm and Happy

5. Reignite that sparkle in your dog’s eyes.

6. Boost your dog’s brainpower.

7. From Nap Mode to Play Mode: Where All That Energy Comes From

How Will Your Dog Thrive With Pawprint Protocol?