Go look at your own kitchen counter for a second.

There's probably a supplement lineup on it. NMN or NR. Maybe resveratrol. CoQ10. Omega-3. A pill organizer with the days printed on the lid. You know what NAD+ is, and you know it falls as a body gets older.

You didn't build that shelf overnight. You built it one bottle at a time, each one added after something you read made sense.

Now look down.

He's on the floor by the counter, the way he is every morning. Grey coming in around the muzzle. Seven, nine, maybe eleven years old. And here's the part that stops people cold once they notice it: your morning routine is more advanced than his, and he's the one moving through the aging years on a much faster clock.

He's been eating the same food out of the same bag for five years. His whole supplement plan is a joint chew somebody recommended once. Nobody ever handed you the dog version, so you never built him one.

That isn't neglect. It's a gap nobody bothered to close.

One owner said it better than we could: “I've been taking NMN for three years. It took me two of them to even wonder whether there was a version for him.”

Here's the thing. He isn't running different biology. He's running the same biology, faster. The same fuel-helper molecule. The same decline. The same enzyme that opens up and drains it.

Same science. Same molecule. Smaller patient.

• You take NMN, NR, resveratrol or CoQ10 — or you've read enough to be curious
• You know what NAD+ is, and you know it drops as a body gets older
• You track something about yourself: sleep, steps, bloodwork, a ring or a watch
• Your dog eats the same food out of the same bag he's eaten for years
• His whole supplement plan is a joint chew somebody recommended once
• He's seven or older, which is where most canine nutrition research starts
• You've never once gone looking for the dog version of what's on your shelf

If three or more of those landed, you're not a careless dog owner. You're an informed one who was never handed the translation. So here it is.

NAD+ is a small helper molecule, and cells use it in hundreds of everyday jobs — turning food into energy, repairing DNA, running the crew that keeps a cell working. Almost every other cellular process leans on it.

It declines with age. That part everyone has heard. What gets skipped is that the decline isn't one problem. It's three at once.

One: less gets made. Older cells produce less of it.

Two: more gets drained. An enzyme called CD38 climbs with age, and its job is to consume NAD+. Supply shrinks while spending rises.

Three: what's left works less efficiently. Mitochondria — the tiny power plants inside every cell — get worn and make less energy from the same input.

Picture a fuel tank with three slow leaks. Not a dramatic failure — a slow, quiet, compounding one.

One honest note, because this subject attracts people who read the papers: the tidy “50% drop by middle age” figure you see online overstates how clean the data is. The decline is well established in rodent tissue and shown in certain human tissues, and how big it looks depends on which tissue you measure. Directionally solid. Precisely quantified, not yet.

And one thing that matters more than all of it: not every change in an older dog is normal aging. Some are medical conditions that look similar and need a vet, not a supplement. If something changed fast, or on one side only, get him seen.

Add up your own shelf. NMN alone runs most people $40 to $80 a month. Add resveratrol, CoQ10, omega-3, the panel you order twice a year. For a lot of people it's a few hundred dollars a month, spread across enough subscriptions that it stopped feeling like a decision long ago.

And it was worth it. That's not the point. Keep the shelf.

The point is what sat next to it. Over those same years, the dog on the floor got a bag of food and a chew — not because you decided he didn't deserve better, but because nobody ever put the dog version in front of you.

So what's actually going on inside him?

The high-demand tissue shows it first. Muscle, brain and heart cells are packed with mitochondria because they burn the most energy, so those are where you notice it — the pause before he gets up, the shorter walk, the toy he stops bringing you. That isn't him giving up. It's a cell-level fuel problem showing up as behavior.

Here's what makes it worth acting on early. Cells run on spare capacity, and the body burns quietly through that reserve long before anything shows. So by the time you see a change, you're not seeing the beginning of it — you're seeing the point where the reserve got thin enough to notice.

That's the real reason “wait and see” is such an expensive strategy with a dog. Not because anything dramatic is coming. Because the quiet part already happened.

Pawprint Protocol was built by people who already had the shelf. They were taking NMN themselves, they understood why, and they couldn't find anything honest built for a dog.

Working with veterinary advisors, they built a daily liquid around one job: give a dog's cells the building block they use to make NAD+, and deliver it in a form that survives the trip.

The lead active is NMN — the direct building block for NAD+, and the one ingredient in the formula with published dog research behind it. In a study of beagles given oral NMN, the compound was well tolerated and raised NAD+ levels in the liver. A real dog study, not a mouse result borrowed and hoped about.

And in 2024 this lane finally got a proper trial in dogs. Veterinary researchers at NC State ran 70 senior dogs through a blinded, placebo-controlled study of an NAD+ precursor paired with a senolytic, and owner-scored cognition improved against placebo at three months. That was a different product, not this one — it proves nothing about Pawprint Protocol. What it shows is that this pathway is worth taking seriously in dogs, not just mice.

Two questions always come up here, so let's answer them straight.

No, don't split your own capsule. A human NMN dose isn't scaled to a dog's bodyweight, and plenty of human formulas carry sweeteners, fillers or extra actives that have no business in a dog. Eyeballing a human capsule for a 60-pound animal isn't the informed move. It's the careless one.

And yes, absorption is most of the game. A lot of what goes on a dog's dinner never makes it in. Stomach acid, first-pass loss, powders that don't dissolve — the label promises one thing and the cell receives another. If you've ever given a chew that did nothing, this is usually why. That wasn't your judgement failing. It was a delivery problem.

Pawprint Protocol is a liposomal liquid. Each active is wrapped in a protective shell so more of it arrives intact instead of breaking down on the way. Built to be absorbed, not just swallowed.

Walk into any pet store and the senior shelf is a wall of joint chews. Cushion the joint. Coat the joint. Ease the joint.

Joints matter. But a joint doesn't move itself, and a joint isn't where the fuel problem lives. If the joint were the whole story the chews would have worked — and for a lot of people reading this, they didn't.

Pawprint Protocol works a level below that, at the cell that has to power everything the joint is attached to. A few drops on the food he already eats, once a day.

Four actives, each with a job:

• NMN: The direct building block cells use to make NAD+, the fuel-helper molecule that naturally declines with age. The hero of the formula, and the one with published dog research behind it.
• NAD+: Included as part of the same pathway, supporting the cellular energy system every high-demand tissue runs on.
• Resveratrol: A plant compound studied alongside NAD+ for its role in the cell's energy and repair signaling.
• CoQ10: Sits inside the mitochondria — the tiny power plants in every cell — where energy actually gets made.

All four in a liposomal liquid, which is the part that decides whether any of it reaches the cell.

✔ Supports the cellular energy that naturally declines with age
✔ Supports normal energy and mobility in senior dogs
✔ Built to be absorbed, not just swallowed
✔ Works alongside any food (kibble, raw, fresh, home-cooked)

Made for dogs 7 and up. Individual results may vary.

You don't have to wait three months to see anything. Most owners tell us the first changes show up in days to weeks, and they rarely arrive as one big moment. They arrive as small things you'd have written off if you weren't paying attention. Here's the pattern owners describe most often. Individual results may vary.

Nothing cinematic. He gets up off the floor on the first try instead of the second. He finishes the bowl instead of leaving a third of it. He's at the door before you've got your shoes on. One owner wrote that the first thing she noticed wasn't energy at all — it was that he started coming to find her in the kitchen again, something he'd quietly stopped doing.

This is where owners start telling other people about it. The walk gets longer without you pushing for it. He picks the route instead of following it. One owner wrote, “he's back to walking in front of me instead of behind me, and I hadn't realized how long that had been going on.”

By now it's less about single moments and more about them repeating. The good day stops being the exception. Owners often mention play here — a toy picked up unprompted, a stretch down into a play bow, a lap around the yard that used to happen once a month and now happens most evenings.

For a lot of families this is the one they write in about, and it's the least dramatic of the four: they stop noticing. The pause before he stands is gone, so they stop watching for it. The stack of good days just became the week.

Three months in, the goal shifts from noticing changes to holding them. NAD+ keeps declining with age and CD38 keeps climbing, so the dogs who hold their ground are the ones who stay on it. Same principle you already apply to your own shelf. Individual results may vary.

You built the shelf for yourself because you read the science and decided not to wait for symptoms. That was the right call.

He's running the same biology you were reading about. Same molecule, same decline, same three leaks — just on a clock that moves a lot faster than yours.

The only thing missing was a version built for him: at his size, in a form he'd actually absorb.

Before the next bottle you order for yourself, order the translation.

Reviews are unedited excerpts from verified Trustpilot reviews of Pawprint Lab. Individual results may vary.

[1] You, J. et al. Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. Frontiers in Pharmacology, 2020.

[2] Camacho-Pereira, J. et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction Through an SIRT3-Dependent Mechanism. Cell Metabolism, 2016.

[3] Age-Dependent Decline of NAD+ — Universal Truth or Confounded Consensus? Nutrients, 2022.

[4] NAD+ Precursor Supplementation in Human Ageing: Clinical Evidence and Challenges. Nature Metabolism, 2025.

[5] Mitochondrial Aging and Age-Related Dysfunction of Mitochondria. BioMed Research International, 2014.

[6] Frailty in Older People (physiological reserve, redundancy and the symptomatic threshold). The Lancet, 2013.

[7] Simon, K.E. et al. A Randomized, Controlled Clinical Trial Demonstrates Improved Owner-Assessed Cognitive Function in Senior Dogs Receiving a Senolytic and NAD+ Precursor Combination. Scientific Reports, 2024;14:12399. (Study of a different product; cited as category evidence, not as evidence for Pawprint Protocol.)