Type of Ingredient
Coenzyme

Purpose
NAD⁺ is like the spark plug of life. It keeps energy production, DNA repair, and cellular defenses running. But oral NAD⁺ is unstable, so we pair it with NMN, a proven precursor, to keep this vital molecule flowing and support long-term cellular health.

Supporting Studies
Loftus JP, Baxter TL, et al. "A randomized, double-blind, placebo-controlled clinical trial of a senolytic and NAD precursor in senior dogs." Scientific Reports, 2024.

Shen H, Ieronimakis N, et al. "Nicotinamide supplementation improves muscle pathology in a canine model of Duchenne muscular dystrophy through enhanced NAD⁺ metabolism." NPJ Regenerative Medicine, 2023.

Type of Ingredient
Mitochondrial Cofactor / Antioxidant

Purpose
CoQ10 lives in the mitochondria, the "power plants" of your dog's cells, where it helps turn food into usable energy. It also works as an antioxidant, protecting cells from wear and tear. Supplementing CoQ10 helps dogs maintain healthy energy levels and support strong muscles and heart function as they age.

Supporting Studies
Druzhaeva N, Kovacevic A, et al. "Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 supplementation on plasma coenzyme Q10 concentration in dogs with myxomatous mitral valve disease." American Journal of Veterinary Research, 2021.

Druzhaeva N, Kovacevic A, et al. "Effects of Coenzyme Q10 Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations and Clinical Status in Dogs with Myxomatous Mitral Valve Disease." Antioxidants, 2022.

Kovacevic A, Druzhaeva N, et al. "Myocardial Coenzyme Q10 concentrations in dogs with naturally occurring myxomatous mitral valve disease." Antioxidants, 2021.

Type of Ingredient
Polyphenol

Purpose
Resveratrol is a natural compound found in grapes and berries. In dogs, it helps strengthen immune defenses, supports a balanced stress response, and protects cells from oxidative damage, helping them stay healthier and calmer in everyday life.

Supporting Studies
Mathew LM, Woode RA, Axiak-Bechtel SM, Amorim JR, DeClue AE. "Resveratrol Administration Increases Phagocytosis, Decreases Oxidative Burst, and Promotes Pro-Inflammatory Cytokine Production in Healthy Dogs." Veterinary Immunology and Immunopathology, 2018.

Bian Z, Li Z, Chang H, Luo J, Jian S, Zhang J, Lin P, Deng B, Deng J, Zhang L. "Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism." Antioxidants, 2025.

Johnson WD, Morrissey RL, Usborne AL, Kapetanovic I, Crowell JA, Muzzio M, McCormick DL. "Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity." Food and Chemical Toxicology, 2011.