UPDATE — This article explains why so many senior dogs stop taking the supplements their owners buy them, and what owners are doing about it. Read the full formula breakdown [HERE].

Every Dog Owner Ends Up With A Drawer Full Of Pill Pockets And Cheese. Here's What Vets Say Nobody Tells You About Why He Started Turning Them Down.
Reviewed by Dr. Mark Saraiva, DVM

Updated on 8/13/2026

Senior chocolate Labrador turning away from a full bowl of kibble in a warm kitchen

Go look in your kitchen for a second.

There's probably a bag of pill pockets in a drawer. A block of cheese in the fridge that isn't really for you. A jar of peanut butter you bought for one specific reason. Maybe a pill splitter. A tub of chews he loved for three weeks and then stopped touching.

You didn't plan any of that. You bought it one piece at a time, each one solving the same small problem a new way. And every single one of them worked — for a while.

Here's the thing nobody says out loud: you have been quietly building a system to trick your own dog into taking the thing that was supposed to help him.

The supplement aisle was happy to sell you the chew. Nobody mentioned he'd have to eat it every day, for months, before it could mean anything at all.

And there's usually one moment in that whole sequence that lands harder than the rest. It isn't the pill you find on the floor. It's the morning he walks up to his bowl, sniffs it, and walks away.

One owner described it exactly: “He recently wasn't eating kibble like he used to so we mix a soft gravy in.”

He's not being difficult. Something about that bowl changed for him — and the bowl was the one place you'd been hiding everything.

That's not stubbornness and it isn't him being spoiled. There's a reason dogs get harder to dose as they age. And there's a reason it matters more than almost anything printed on the label.

Kitchen counter with pill pockets, cheese, peanut butter and a pill splitter used to hide dog supplements
7 Signs You've Been Fighting To Get A Supplement Into Him
  • There's a bag of pill pockets, a block of cheese, or a jar of peanut butter in your kitchen that's really for him
  • You've found a pill or a chew on the floor, behind the bowl, or under the couch
  • He eats around the supplement and leaves it sitting in an otherwise empty bowl
  • He liked a chew for a few weeks, then quietly started refusing it
  • You've split, crushed, wrapped, or buried a dose just to get it down him
  • Some mornings you skip it, because it isn't worth the fight before work
  • You've never once been sure how much of it actually went in


Dog bowl eaten clean around a single supplement chew left untouched in the centre

If you recognized three or more of those, you're not looking at a picky dog. You're looking at a dosing problem — and it decides whether a supplement can do anything at all.

Here's what most owners never get told. Every dose has to clear two gates before it can help. The first gate is his mouth. The second gate is his gut. Almost everyone only ever thinks about the first one.

Older dogs get harder at that first gate for very ordinary reasons. Smell drives appetite in dogs, and it dulls with age, so food simply gets less interesting. Teeth and gums get sore, so a hard chew stops being worth the work. And dogs learn fast — one bitter surprise inside a treat and the treat itself goes on the no list for good.

So the standoff at dinner isn't him being stubborn. It's him doing the math.

Then there's the second gate, which nobody in that aisle mentions at all. It's the one that quietly decides how much of what you paid for ever reaches him.

One important thing first: a real drop in appetite is not the same as fussiness. If he's suddenly off his food, dropping weight, or it came on fast, that's a vet visit, not a supplement question.

Diagram: The Two Gates Every Dose Has To Clear - the bowl and the gut
A Dose He Doesn't Take Is A Zero. What 15,000+ Dog Parents Switched To Instead.

Add up what's already in your kitchen. The pill pockets. The cheese. The peanut butter. The tub of chews he quit on. For most owners it's a couple of hundred dollars a year, spread so thin it never felt like a decision.

And none of it was silly. Hiding a dose is a kind thing to do. It's just that hiding it only ever solves the first gate.

So what happens at the second one?

Everything he swallows takes a trip. Down into stomach acid, through the gut wall, then straight through the liver before it reaches the rest of the body. Fragile ingredients lose a share at every step. That's normal biology, and it happens to every supplement ever made.

Some ingredients have a harder trip than others. Things like CoQ10 and resveratrol are fat-loving — they don't dissolve well in water, and in a dry powder or a hard chew they can move straight through, poorly mixed and barely picked up.

Which leads to the uncomfortable part. The number on the label is how much went into the product. It was never a promise about how much reaches your dog.

If you've ever bought a supplement that seemed to do nothing, this is usually why. That wasn't your judgement failing. It was a delivery problem.

Infographic: Three Ways A Daily Dose Goes Missing - refusal, breakdown and poor mixing
Why Over 15,000 Dog Parents Went From A Chew To A Dropper

Pawprint Protocol was built by owners who were tired of losing the fight at dinner.

Working with veterinary advisors, they built a daily liquid around two jobs at once: give cells the building block they use to make NAD+, and put it in a form that clears both gates instead of just one.

The lead active is NMN — the direct building block for NAD+, the fuel-helper molecule cells use for hundreds of everyday jobs. It's also the one ingredient in the formula with published dog research behind it. Oral NMN has been studied in dogs and raised NAD+ levels in the liver.

Then there's the delivery, which is the part most supplements treat as an afterthought. Pawprint Protocol is a liposomal liquid. Each active is wrapped in a tiny fat-based shell that shields it on the way through, so more of it arrives intact instead of breaking down before it gets there.

And it clears the first gate almost by accident. It isn't a pill and it isn't a chew. It's a few drops from a dropper onto whatever he already eats — kibble, raw, fresh, or the spoon of gravy you're already using to get him interested.

Nothing to hide. Nothing for him to spit out. Owners tell us the first thing they notice isn't in the dog at all — it's that dinner stopped being a negotiation.

Pawprint Lab daily liquid supplement bottle on a kitchen counter beside a bowl of kibble
Stop Hiding It In His Food. Just Put It On His Food.

Walk into any pet store and the senior shelf is a wall of chews. Bigger chews, softer chews, chews shaped like bacon. Every one of them built on the same assumption — that your dog will eat it.

For a lot of dogs at seven, ten, thirteen years old, that assumption quietly stops being true. And a chew he won't eat isn't a weak dose. It's no dose.

Pawprint Protocol goes on the food instead of pretending to be food. A few drops from the dropper, once a day, on whatever is already in the bowl.

Four actives, each with a job:

  • NMN: The direct building block cells use to make NAD+, the fuel-helper molecule that naturally declines with age. The hero of the formula, and the one with published dog research behind it.
  • NAD+: Included as part of the same pathway, supporting the cellular energy system the whole body runs on.
  • Resveratrol: A plant compound studied alongside NAD+ for its role in the cell's energy and repair signaling. Fat-loving, which is exactly why the liquid form matters.
  • CoQ10: Sits inside the mitochondria — the tiny power plants in every cell — where energy actually gets made. Also fat-loving, and also hard to take in dry.


All four in a liposomal liquid, which is the part that decides whether any of it gets where it's going.

✔ No pills, no chews, no pill pockets, no cheese
✔ Supports the cellular energy that naturally declines with age
✔ Built to be absorbed, not just swallowed
✔ Goes on any food — kibble, raw, fresh, home-cooked, gravy

Made for dogs 7 and up. Individual results may vary.

Dropper adding drops of Pawprint Lab liquid onto a bowl of kibble while a senior dog waits
The First 90 Days — What Owners Tell Us They Notice

You don't have to wait three months to see anything. Most owners tell us the first change shows up within a day or two — and it isn't in the dog, it's in them. Here's the pattern owners describe most often. Individual results may vary.

Timeline: The First 90 Days of a daily liquid supplement routine
1. Days 1–14 — The Fight Just Stops

This is the fast one. Drops go on dinner, dinner gets eaten, and nobody had to wrap anything in cheese. One owner wrote that the strangest part of the first week wasn't her dog at all — it was standing at the counter and realising she didn't need to open the fridge first.

Empty dog bowl licked completely clean on a wood floor
2. Weeks 3–6 — The Drawer Stays Shut

The workarounds go quiet. The pill pockets sit unopened. The cheese goes back to being cheese. And because nothing is getting skipped or spat out any more, this tends to be where owners start describing the dog instead of the routine — a bit more interest at dinner, a bit more up-and-about in the evening.

Kitchen drawer with unused pill pockets and a pill splitter pushed to the back
3. Weeks 7–9 — The Streak Holds

By now it's just part of the evening. No negotiation, no hiding, no days lost to a busy morning. Owners often say this is the first supplement they've ever actually finished the bottle of — and the first one where they knew, every single day, that he'd had it.

Senior Labrador trotting eagerly toward his dinner bowl
4. Weeks 10–12 — The Part That Actually Adds Up

Here's the quiet truth about every daily supplement: the dose he takes on a Tuesday you barely remember is worth more than the perfect one he refused. Consistency is the whole game — and consistency is exactly what a chew he won't eat can never give you.

Three months in, the goal shifts from getting it into him to simply keeping it going. NAD+ keeps declining with age, so the dogs who hold their ground are the ones who stay on it. And the easiest supplement to stay on is the one nobody has to fight about. Individual results may vary.

Senior Labrador resting contentedly in the evening with the Pawprint Lab bottle on a shelf behind him
Real Owners. Real 90-Day Notes.

“Beau is 7 and was already slowing down, having trouble getting up... I tried so many different things to help him. It wasn’t until I tried PawPrints liquid nutrients that I finally have my dog back. We are headed into month 3 and today he brought me his Frisbee for the first time in over a year and jumped for it. I thought I never see that again.”

Nancy W. — Trustpilot Review

“My dog is typically picky but she loves this and it doesn’t bother her at all! Shes a bernese mountain dog and prone to joint issues and I’ve already noticed more pep in her step!”

Ashley V. — Trustpilot Review

“Mahrosh was very helpful in getting my third bottle sent out early. These drops seem to be helping our eleven year old Staffordshire get along a bit better. Customer service is great and very responsive. Hopefully this next bottle we’ll continue to see improvement.”

Pamela S. — Trustpilot Review

You bought the pill pockets because you love him. That was never the wrong call.

But every one of those workarounds was you solving a problem the product should have solved itself. A supplement's first job isn't to look impressive on a label. It's to actually get into the dog, every day, without a fight.

So before the next tub of chews, ask the simpler question: will he still be taking it tomorrow, and the day after, and the day after that?

Reviews are unedited excerpts from verified Trustpilot reviews of Pawprint Lab. Individual results may vary.

Pawprint Protocol — Daily Cellular Energy Support For Senior Dogs
  • Liposomal liquid — built to be absorbed, not just swallowed
  • NMN, NAD+, Resveratrol and CoQ10 in one dropper
  • A few drops on the food he already eats — no pills, no chews
  • Made for dogs 7 and up — trusted by 15,000+ dog owners
  • Made in the USA in a cGMP facility, third-party lab tested

Every pill pocket in your kitchen was you solving a problem you were never given a name for. Now it has one: a dose he won't take is a dose of zero, and the best formula in the world can't get past a closed mouth.

Pawprint Protocol goes on the food he already eats — no hiding, no wrapping, no negotiating — in a liquid built to survive the trip and reach the cells that use it.

A few drops on dinner. That's the whole routine. Individual results may vary, and check with your vet if your dog is on medication or if his appetite changed suddenly.

References

[1] You, J. et al. Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration. Frontiers in Pharmacology, 2020.

[2] Structural Degradation and Uptake of Resveratrol-Encapsulated Liposomes Using an In Vitro Digestion Model Combined With a Caco-2 Cell Monolayer. Food Chemistry, 2023.

[3] Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles. International Journal of Molecular Sciences, 2018.

[4] A Novel Lipid-Free Nanoformulation for Improving Oral Bioavailability of Coenzyme Q10. BioMed Research International, 2014.

[5] Age-Dependent Decline of NAD+ — Universal Truth or Confounded Consensus? Nutrients, 2022.

[6] Camacho-Pereira, J. et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction Through an SIRT3-Dependent Mechanism. Cell Metabolism, 2016.