
Dogs typically start showing signs of aging, including health issues and cognitive decline, at around 7 years old. Cognitive decline similar to dementia begins appearing around 8-10 years. Signs may include disorientation, confusion, and altered sleep patterns, though timing varies by breed and size.
Pawprint Protocol works to help address this decline by providing your dog's system with essential nutrients.
reduction in cognitive decline markers within 90 days*
of dogs showed improved heart health indicators in just 4 weeks*
less age-related muscle loss after 6 weeks*
*Backed by peer-reviewed studies on the individual ingredients
Pawprint Protocol follows the highest ethical standards when creating our supplements. We ensure your pooch gets the best ingredients from the safest labs and manufacturers in America.
We offer a 90-day money-back guarantee on website orders.
Katherine E. Simon, Katharine Russell, Alejandra Mondino et al. “A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD⁺ precursor combination.” Scientific Reports 14:12399 (2024).
Ming You, Xiumei Fan, Liang Tao et al. “Sub-acute toxicity study of nicotinamide mononucleotide via oral administration in beagle dogs.” Toxicology Reports 8:40–52 (2021).
Déborah Cardoso, Inès Barthélémy, Stéphane Blot et al. “Replenishing NAD⁺ content reduces aspects of striated-muscle disease in a dog model of Duchenne muscular dystrophy.” Skeletal Muscle 13:20 (2023).
Zhaowei Bian, Ziyang Li, Hao Chang et al. “Resveratrol ameliorates chronic stress in kennel dogs and mice by regulating gut microbiome and metabolome related to tryptophan metabolism.” Antioxidants 14(2):195 (2025).
Rachel L. Poole, Emily R. Woodall, Philip K. Byers et al. “Pharmacokinetic analysis of an oral multicomponent joint dietary supplement (containing trans-resveratrol) in dogs.” Pharmaceutics 9(3):30 (2017).
Ainara Tvarijonaviciute, Pablo Escribano-Durán, Aránzazu Torre-Noguera et al. “Effects of Coenzyme Q10 supplementation on oxidative stress and clinical status in dogs with mitral valve [issues].” Antioxidants 11(8):1427 (2022).
Liselotte B. Christiansen, Malene K. Morsing, Maria J. Reimann et al. “Pharmacokinetics of repeated oral dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with myxomatous mitral valve [issues].” Antioxidants 9(9):827 (2020).